Cholinergic stimulation with pyridostigmine, hemodynamic and echocardiographic analysis in healthy subjects
نویسندگان
چکیده
منابع مشابه
Cholinergic stimulation with pyridostigmine, hemodynamic and echocardiographic analysis in healthy subjects.
OBJECTIVE Growing evidence suggests that sudden death after an acute myocardial infarction (AMI) correlates with autonomic nervous system imbalance. Parasympathomimetic drugs have been tested to reverse these changes. However, their effects on ventricular function need specific evaluation. Our objective was to analyze pyridostigmine's (PYR) effect on hemodynamic and echocardiographic variables ...
متن کاملExercise stress testing in healthy subjects during cholinergic stimulation after a single dose of pyridostigmine.
OBJECTIVE The evaluation, by exercise stress testing, of the cardiorespiratory effects of pyridostigmine (PYR), a reversible acetylcholinesterase inhibitor. METHODS A double-blind, randomized, cross-over, placebo-controlled comparison of hemodynamic and ventilation variables of 10 healthy subjects who underwent three exercise stress tests (the first for adaptation and determination of toleran...
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Mentally or emotionally stressful situations occur throughout our lives and cause physiological haemodynamic responses. In patients with coronary artery disease, such events can also induce myocardial ischaemia and ventricular arrhythmias, increasing mortality rates. The purpose of the present study was to determine the acute effects of the oral administration of pyridostigmine, a reversible ch...
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Pyridostigmine bromide (PB) is a reversible cholinesterase inhibitor. The aim of this study was to determine the effect of orally administration of single dose sustained-released tablet of pyridostigmine bromide (PBSR) on the frequency domain indices of heart rate variability (HRV). Thirty-two healthy young men were participated in this study. They were divided into 2 groups; the pyridostigmine...
متن کاملCholinergic stimulation with pyridostigmine protects against exercise induced myocardial ischaemia.
OBJECTIVE To determine the acute effects of pyridostigmine bromide, a reversible cholinesterase inhibitor, during exercise in patients with coronary artery disease. DESIGN Double blind, randomised, placebo controlled, crossover study. SETTING Outpatients evaluated in an exercise test laboratory. PATIENTS 15 patients with exercise induced myocardial ischaemia. INTERVENTIONS Maximal cardi...
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ژورنال
عنوان ژورنال: Arquivos Brasileiros de Cardiologia
سال: 1999
ISSN: 0066-782X
DOI: 10.1590/s0066-782x1999000300003